Resources

Proteomics Databases



Metabolomics Databases

• • Mechanism of PCT-DIA Proteomics

  Proteomics, the field dedicated to the study of the structure, function, and interactions of proteins within a biological system, is fundamental to advancing our understanding of life sciences. The integration of Pressure Cycling Technology (PCT) with Data-Independent Acquisition (DIA) represents a significant advancement in proteomics, enhancing both the efficiency and precision of analysis.

• • Workflow of PCT-DIA Proteomics

  PCT-DIA (Pressure Cycling Technology-DIA) is an advanced analytical approach in modern proteomics. By combining Pressure Cycling Technology (PCT) with Data-Independent Acquisition (DIA), this method facilitates efficient, comprehensive, and highly sensitive analysis of complex protein samples. PCT-DIA not only improves protein identification rates but also significantly enhances the accuracy of quantitative data, establishing itself as a pivotal tool in proteomics research.

• • Advantages and Disadvantages of PCT-DIA Proteomics

  PCT-DIA (Pressure Cycling Technology-DIA) is a proteomics analysis method that combines Pressure Cycling Technology (PCT) with Data-Independent Acquisition (DIA). This technique enhances protein lysis efficiency by alternating between high and low pressures, allowing for comprehensive protein quantification using DIA.

• • Principle of PCT-DIA Proteomics

  PCT-DIA, an advanced technique in mass spectrometry, is designed to enhance the sensitivity and accuracy of protein identification and quantification. By integrating Pressure Cycling Technology (PCT) with Data-Independent Acquisition (DIA), PCT-DIA shows significant potential in proteomics research.

• • Phosphoproteomics Analysis

  Phosphoproteomics analysis is a large-scale analytic technique used to comprehensively study protein phosphorylation modifications. This analytic method can not only identify the phosphorylation sites but also quantify the changes in protein phosphorylation levels under different conditions, thereby revealing the complex regulatory mechanisms of protein functions and cellular signaling networks.

• • Construct Sequence Graph: Application of Protein Group Mass Spectrometry Analysis LC-MS/MS

  Proteins are the most basic functional molecules in biological organisms and are of great significance for understanding the structure and function of organisms. However, the complexity of proteins makes their research challenging. To solve this problem, scientists have developed a technology called proteome mass spectrometry analysis, where Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS) is one of the most commonly used methods.

• • HDX Hydrogen-Deuterium Exchange in Recombinant Protein Drugs

  Recombinant protein drugs refer to protein products that are derived from animals and plants and developed through biotechnology. They have certain biological activity and can be used to prevent, treat, and diagnose diseases in humans, animals, and plants. Compared with small molecule drugs, protein drugs have advantages such as high activity, high specificity, and low toxicity, which attract a lot of researchers.

• • Analysis of Free Toxins in ADC Drugs

  Antibody-Drug Conjugates (ADC) are effective target therapy drugs for tumors, composed of monoclonal antibodies with specific targeting effects, small molecule cytotoxins with strong cell killing power, and their connectors. The key feature of ADC drugs is the combination of highly selective monoclonal antibodies with toxic drugs through chemical connection.

• • HPLC Purity Analysis of Peptide Drugs

  Peptides are large biological molecules formed by the connection of two or more amino acids through peptide bonds. Peptide drugs have become a research hotspot in the field of biomedicine in recent years, mainly having two advantages: First, peptide drugs possess high specificity and efficiency as they can target specific proteins or receptors in the body; Second, peptide drugs usually have good biocompatibility and low toxicity as they are based on naturally existing biomolecules.

• • Antibody Drug Monosaccharide Spectrum Analysis

  Antibody drugs are a significant advancement in the biopharmaceutical field in recent years, widely used in various diseases, especially in the treatment of cancer and autoimmune diseases. They mainly exert their therapeutic effects by recognizing and binding to specific antigens. This specificity makes antibody drugs have higher selectivity and reduced side effects in treatment. However, the safety, stability, and functionality of antibody drugs largely depend on their glycan structures.