Resources
Proteomics Databases
Metabolomics Databases
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Proximity labeling assay is a widely employed experimental technique in proteomics research that aims to efficiently identify and investigate protein interactions, intracellular localization, and functions. This method enables researchers to precisely label proteins and their interacting neighbors, revealing their roles and biological processes within cells. The core principle involves using specialized labeling molecules (such as enzymes or chemical reagents) to tag proteins and adjacent molecules. S......
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Proteomic mapping systematically characterizes the protein composition, structure, and function of a specific organism, tissue, or cell under defined conditions. As an integral part of proteomics research, it provides critical insights into protein expression levels, post-translational modifications, interaction networks, and their functional roles in biological systems. With advances in high-throughput technologies, proteomic mapping has become a key tool for studying biological processes and is wide......
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TMT phosphoproteomics is a high-throughput method based on TMT quantitative labeling technology, aimed at studying the dynamic changes in protein phosphorylation and their regulatory roles in cellular signaling, disease progression, and drug effects. As one of the post-translational modifications, protein phosphorylation is crucial in various biological processes, including cell cycle regulation, metabolic control, and immune response. By integrating enrichment strategies for phosphorylation and high-......
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Activity-based proteomics is an emerging field focused on uncovering protein functions and dynamic changes by assessing their biological activities within cells. Unlike traditional proteomics, which primarily examines protein expression profiles, this field emphasizes understanding the functional states, interactions, and roles of proteins in biological processes. Central to this discipline is identifying and quantifying active proteins, which gain biological activity through specific chemical modific......
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Proteomics network analysis is a scientific approach that integrates bioinformatics, statistics, and systems biology to explore protein interactions and functions within biological systems. Central to this method is the construction of protein interaction networks that elucidate the intricate relationships of proteins in cellular contexts and their roles in various biological pathways. This analysis has broad applications, ranging from fundamental biological research to clinical medicine. In foundatio......
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Peptide analysis services are integral to biological research, focusing on the identification and characterization of peptides generated from protein digestion under specific conditions. These services leverage precise experimental protocols and advanced analytical techniques, making them essential tools in the life sciences. They facilitate a deeper understanding of protein structures and functions and are critical to studies in protein function, biomarker identification, and drug development. In the......
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• Acetylation Proteomics with Mass Spectrometry
Acetylation proteomics is a scientific discipline focused on examining protein acetylation modifications and their impact on cellular functions. Acetylation is a widespread post-translational modification (PTM) that influences the function, stability, interactions, and localization of proteins through the addition of acetyl groups to lysine residues. The objective of this research area is to comprehensively identify and quantify acetylated proteins within cells to uncover their roles across various bi......
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• 6 Powerful Protein Molecular Weight Determination Methods
With the advancement of protein research, the methods for determining protein molecular weight have been continuously refined and innovated. MtoZ Biolabs presents 6 powerful protein molecular weight determination methods, enhancing accuracy, sensitivity, and applicability across various protein sample types. Mass Spectrometry (MS) for Protein Molecular Weight Determination 1. MALDI-TOF-MS (Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry) (1) Applications Ideal for small ......
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• Protein Molecular Weight Determination: 10 Steps You Should Follow
Protein molecular weight determination is a crucial experimental step in biomedical research, proteomics, and drug development. To ensure the accuracy and reliability of the results, researchers should follow a systematic methodology. Below are 10 steps that can effectively enhance the precision of protein molecular weight determination: 1. Select the Appropriate Measurement Method Different experimental objectives require different measurement methods. Common techniques for protein molecular weight......
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Light scattering, as efficient and accurate techniques for protein molecular weight determination, have broad applications in biology and biopharmaceuticals. By combining Static Light Scattering (SLS) and Dynamic Light Scattering (DLS), researchers can obtain multidimensional information about protein molecular weight, aggregation states, and stability, which is crucial for protein structural-functional analysis, drug development, and quality control in production processes. As the technology contin......
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