Resources

Proteomics Databases



Metabolomics Databases

• • Principle of Protein Sumoylation Identification

  SUMOylation, involving the covalent attachment of Small Ubiquitin-like Modifier (SUMO) to target proteins, is a critical post-translational modification that regulates diverse cellular processes, including nuclear functions, signal transduction, and transcriptional regulation. Accurate detection of SUMOylation sites and the proteins modified by SUMO is essential for understanding the functional roles of this modification.

• • Workflow of Protein Sumoylation Identification

  Protein SUMOylation (Small Ubiquitin-like Modifier, SUMO) is a critical post-translational modification (PTM) that regulates various cellular processes, including protein function, signaling pathways, and gene expression. Understanding the biological significance of SUMOylation requires precise identification and analysis of SUMOylated proteins.

• • Protein Gel Band Identification: From Cross-Linking to Interaction Analysis

  Protein gel strip identification is a commonly used experimental method that helps researchers determine the interaction relationships between proteins.

• • Circular Dichroism Analysis of Peptide Drugs

  Peptide drugs refer to a category of drugs that use peptides for the treatment of diseases. As one of the hotspots in drug development, peptide drugs have significant efficacy, strong specificity, and low toxicity. They are widely used in the treatment of various diseases, including metabolic diseases, neurological diseases, immune diseases, and tumors.

• • Purity Analysis of Antibody Drugs (CE-SDS, SDS-PAGE, SEC, RP, etc.)

  Antibody drugs are a class of drugs that treat diseases through artificially synthesized antibodies. They achieve therapeutic purposes by specifically binding to target molecules. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, antibody-drug conjugates, etc.

• • NMR Analysis of Peptide Drugs

  Polypeptide drugs are large biomolecules formed by the connection of dozens to hundreds of amino acids via peptide bonds. Their biological activity and stability depend on their three-dimensional structure, making the analysis of their structure crucially important.

• • Glycosylation Sites (N-Glycosylation, O-Glycosylation) Detection for Antibody Drugs

  Antibody drugs are a class of drugs that use antibodies to specifically recognize and bind to target molecules. Glycosylation is a critical type of post-translational modification that can affect the stability, biological activity, and immune response of antibody drugs. Glycosylation typically occurs at the N (asparagine) and O (serine or threonine) sites of the antibody.

• • Recombinant Protein Drug Process Impurity Analysis

  Recombinant protein drugs are produced using bioengineering technology, a process that may introduce certain process impurities. These impurities include host cell proteins (HCP), host cell DNA (HCD), protein A, and some substances added during production, such as defoaming agents. These impurities may affect the safety, stability, and biological activity of the drug.

• • Determination of the Extinction Coefficient for Recombinant Protein Vaccines

  Recombinant protein vaccines are a type of vaccine that does not contain a complete pathogen and are made up of specific protein antigens produced by a heterologous expression system. Common heterologous expression systems include bacteria, mammalian cells, plant cells, and insect cells, and the appropriate heterologous expression system often needs to be selected according to the type of antigen produced.

• • Proteomics Mass Spectrometry: Decoding Protein Structures

  Proteomics mass spectrometry technology plays a vital role in understanding the structure and function of proteins, uncovering the mysteries of life, studying disease mechanisms, and developing new drugs.