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    De Novo Sequencing Service

      Accurate determination of protein sequences is fundamental in the development of commercial monoclonal antibodies, vaccines, and diagnostic kits. Traditional sequencing methods uses database searching for protein sequencing, and has limitations for sequencing the unknown proteins, which may not be included in the database. De novo sequencing is a novel sequencing methods, with no need for database searching, and therefore, is the optimal method for analyzing unknown proteins and antibodies. Based on the world's most advanced mass spectrometry instrument, Obitrap Fusion Lumos, and combined with rich experience in bioinformatics analysis, MtoZ Biolabs has established a whole new generation of de novo sequencing platform that can achieve accurate sequence analysis of monoclonal antibodies and proteins, independent of any database searching. The primary sequence of proteins and antibodies and any mutations on the sequence can be analyzed quickly and accurately, without any prior information of the protein.


      Advantage of De Novo Sequencing

      1. Advanced High-Resolution Mass Spectrometry Technology

      2. 100% Protein/Antibody Sequence Coverage

      3. 95% Accuracy for Sequencing the First Amino Acid

      4. Minimum Amount of Sample Required


      De novo Sequencing


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      Antibody De Novo Sequencing

      MtoZ Biolabs is proud to offer antibody de novo sequencing service, using high-resolution Obitrap Fusion Lumos mass spectrometry.


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      Protein De Novo Sequencing

      MtoZ Biolabs develops an advanced mass spectrometry platform and ensures high-efficient and accurate protein de novo sequence analysis.


      Related Services

      Protein Sequencing

      Protein De Novo Seq

      N-Terminal Sequencing

      C-Terminal Sequencing

      Edman Degradation

      Protein Full-Length Sequencing


      Protein Analysis

      Protein Identification

      Protein Mass Measurement

      LC-MS Analysis of Pull-Down Proteins

      Native MS Analysis


      PTM Analysis

      Phospho Proteomics

      Acetyl Proteomics

      Ubiquitin Proteomics

      Glyco Proteomics

      Disulfide Bond

      Histone Modifications

    • • De Novo Peptide Sequencing Service

      There are two common methods for peptide sequence analysis: database search and de novo sequencing. Database searches identify peptide sequences by comparing them in known databases. However, due to incomplete databases for some species, many new or bioactive peptides cannot be matched. De novo peptide sequencing addresses this issue by using tandem mass spectrometry (MS/MS) to determine the amino acid sequence of a peptide without a sequence database. This method allows for the analysis of new and un......

    • • De Novo Protein Sequencing Service

      MtoZ Biolabs uses Orbitrap Fusion Lumos for protein de novo sequencing service with high accuracy and 100 percent sequence coverage.

    • • De Novo Antibody Sequencing Service

      MtoZ Biolabs provides reliable and accurate antibody de novo sequencing service, without the need for a database.

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